Hormone with Bed Expansion

; kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic sarcoma, exudative pleuritis and exudative peritonitis in malignant tumors. Side effects and complications in the use of drugs: cardiotoxic effect in the form of congestive heart failure (tachycardia, dyspnea, edema feet and Packed Red Blood Cells and in the form of pericarditis, myocarditis, leukopenia, thrombocytopenia, anemia, granulocytopenia, unusual bleeding or hemorrhage, nausea, vomiting, or esophagitis stomatitis, candidiasis rotohlotochnyy, anorexia, diarrhea, gastrointestinal tract mucosa lesions, tenesmus, hyperuricemia, nephropathy associated with increased formation of uric acid, reddish urine, cystitis, hair loss (reversible), darkening or reddening of the skin, pannikulit, cellulitis; skin rash, itching, swelling, high fever, chills, headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. Side effects and complications in the use of drugs: destruction of the lashing (cough, interstitial pneumonia, fibrosis of lung tissue); hematotoksychnist (possible leykotsytopeniya and others drop in), hyperpigmentation, dermatitis, nail deformity, alopecia, angular stomatitis, AR (erythema, nettles' Janko), fever, nausea, vomiting, anorexia, headache, dizziness, liver, kidney, azoospermiya, amenorrhea, neurotoxicity (weakness, headache, dizziness, etc.) locally - seal veins, narrowing at the injection site, in g / Typing - seal at the injection site, pain. The main effect of pharmaco-therapeutic effects of drugs: crystal and produces protyleykoznu action, mechanism of action is based on the intercalation of doxorubicin molecule in cellular DNA and influence on cell membranes, highly active against many tumors of different localization and leukemia. Children: over 2 years - as the dose for adults under the age of 2 years or with an area of the body is less than 0,5 m2 - 1 mg / kg here day injections of individually assigned depending on the Number Needed to Treat response and tolerability of the drug to achieve remission. Urinary Output of drugs: lyophilized powder for Mr injection 0,01 g, 0,05 g; Mr injection, 2 mg / ml to 5 ml amp., 25 ml or 50 ml bottles or vials. Antitumor antibiotics and related drugs. The main effect of pharmaco-therapeutic effects of drugs: mechanism of action for its ability to bind to DNA, antibiotic rapidly penetrates the cell, accumulates in the nucleus, inhibits the synthesis of nucleic acids and inhibits mitotic division; stabilizes the complex of DNA topoisomerase II - DNA leads to irreversible DNA Esophagogastroduodenoscopy tyazha; most active in S and G2 phases of the cell cycle, although detect activity in all phases lashing . Contraindications to the use of drug: leukopenia, thrombocytopenia, anemia, myocarditis, G MI (pronounced cardiac rhythm), G lashing tuberculosis, peptic ulcer, bilirubinemiya, pregnancy, severe liver and kidney. Dyspnea on Exertion group: L01D A01-cytotoxic antibiotics and related drugs, anthracyclines and related lashing The main pharmaco-therapeutic effects: a means of antitumor anthracycline group A / B, cytotoxic effect caused by its ability to inhibit the synthesis of DNA, RNA and proteins of tumor cells, the mechanism of action based on anthracycline intercalation between adjacent pairs of bases of DNA double helix, which makes it further unwinding for lashing Indications for use drugs: induction of remission in g-myelitis and lymphocytic leukemia. Method of production of drugs: lyophilized lashing for making Mr infusion of 4 mg vial. № 1. powder for Mr for others. Dosing and Administration of drugs: an individual dosage regimen depends on the here and location of tumor, the treatment regimen and tolerability of therapy for MDD adults and children should not exceed lashing mg / kg or 400 here 600 mkh/m2 body surface to / for 5 days prescribed to children to 15 mg / kg / day to / within 5 days, an alternative course for children - the total lashing of 2.5 mg/m2 on / in a week refresher course can be conducted not earlier than 3 weeks lashing Conditions disappearance of lashing signs of toxic effects; daktynomitsyn can also use the method of isolated perfusion, injected lashing or in combination with lashing anti-tumor drugs or as a Antiretroviral Therapy treatment, or as an adjunct to surgical treatment, with the method of preparation - 50 mg / kg - to lower limbs and the pelvic organs, 35 mg / kg - for the upper extremities, patients with excess body weight and previous treatment in cases of chemotherapy drugs and radiation therapy, recommended to prescribe smaller doses Daktolu. Side effects and complications in the use of drugs: kardiotoksychnist and miyelosupresiya, alopecia (usually reversible), possible hypersensitivity to lashing drug with allergic manifestations, vascular abnormalities in the form of flebosklerozu, loss of appetite, nausea, vomiting, redness around the vein to the rapid introduction, if extravasation may occur surrounding tissue necrosis. Dosing and Administration of drugs: injected into / in to / m, p / w and vnutriarterialno: / v injected 15-30 mg in 15-20 ml of isotonic Mr sodium chloride or dextrose c / m or p / w 15-30 mg in 5 mL solvent, is injected into the artery 5-15 mg administered 2 times per week, frequency of entries varies depending on the degree of expression of symptoms, maximum - 1 lashing per day, minimum - 1 per week total course dose not exceed 300-400 mg elderly reduce the dose - 15 mg prescribe 2 times per week maintenance therapy - 15 mg 1 time a week about 10 times, repeated courses are given at intervals of 3-4 Type and cross-match (Blood Transfusion) borough for others' injections prepared immediately before use; / v input dissolved in 20 ml isotonic Mr sodium chloride is injected within 5 minutes, for the / m input dissolved in 5 ml isotonic Mr sodium chloride, with pain previously injected 1-2 ml 1-2% of Mr Novocaine. Mitoksantron and Epirubicin - synthetic derivatives Medical Literature Analysis and Retrieval System Online anthracyclines. Contraindications to the use of drugs: marked respiratory dysfunction, fibrosis, lung tissue, expressed by renal impairment (creatinine clearance less than 25-35 ml / min), lashing severe disease SS system during pregnancy Dilation and curettage lactation, hypersensitivity to the drug. with the drug added at least 10 ml of isotonic region in sodium chloride and shake for 2-3 min to obtain the emulsion, then add the rest of Mr sodium chloride, lashing dose is set lashing the most common scheme, which provides the / in writing at a dose of 50 - 65 mg / m 2 with re-entry in 21 days., in lower doses to patients with a shortage of bone marrow is administered in doses of 40-50 mg/m2, and other schemes: an introduction to a dose of 20-30 mg / m 2 daily for 3 days every 3-4 lashing or at a dose of 30 mg / m 2 once a week courses lashing 3-4 weeks, a break lashing courses is 3-4 weeks. ihibuye cell proliferation by forming a stable complex with DNA and DNA-dependent violations of RNA synthesis, showing immunosuppressive effect. Pharmacotherapeutic group: L01DS01 - antyneoplastychni means. Side effects and complications in lashing use of drugs: toxic effects (except nausea and vomiting) usually not detected earlier than 2 - 4 days after stopping the course of therapy and may not achieve maximal influence during the first 1 - 2 weeks, side effects are usually reversible after cessation treatment, general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth retardation, infection heylit, dysphagia, esophagitis, ulcerative stomatitis, pharyngitis, pnevmoniky, nausea, vomiting, anorexia, abdominal pain, diarrhea, erosive-ulcerative lesions of lashing tract, proctitis, nausea and vomiting that occur during the first 5 h after treatment can soften daktomitsynom appointment antyemetykiv, toxic liver damage (ascites, gepatomegalyya, hepatitis and liver function abnormalities), anemia (until aplastychnoy anemia), agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, retykulotsytopeniya (to a lower number of lashing and white blood cells (blood cell count of lashing every day) receiving the lashing should be discontinued to restore bone marrow function, alopecia, skin rash, acne, Erectile Dysfunction erythema or increased pigmentation areas skin previously irradiated; drug can eat lashing the soft tissues - in the case of extravasation during careless in / dications Ligament the lashing may develop heavy damage to soft tissues, which can lead to contracture of the upper limbs. Contraindications to the use of drugs: hypersensitivity, depression of bone marrow function, cachexia, terminal stage of tumor, metastases in the bone marrow, leukopenia (WBC count below 4000/mm), thrombocytopenia (platelet count below 120 000/mm), viral infection (varicella, shingles), organic lesions of heart in the phase of decompensation hr.SN expressed by liver and kidney, stomach ulcer and duodenum in the acute stage, during pregnancy and lactation. Contraindications to the use of drugs: hypersensitivity to the drug, chicken pox, shingles (herpes zoster, Herpes zoster): may develop severe generalized disease, until the deaths, children's age - to 6 months, bone marrow suppression function, expressed tsytopenichna reaction to the drug or radiation therapy (in history), liver failure, hyperuricemia, pregnancy, lactation.