In this case, clonidine administered intravenously over 5-7 minutes, with the rapid introduction may in elevated blood pressure because of semiarid a2adrenoreceptors vessels. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and semiarid a lesser extent a2adrenoreceptors. At the same time excited centers vagus (nucleus ambiguus) and inhibitory neurons which have a depressing effect on the RVLM (vasomotor center). By centrally acting antihypertensive drugs include clonidine, Moxon-Din, semiarid methyldopa. Guanetidin not penetrate through gematoentsefa-crystal barrier and does not alter the content catecholamines in the adrenal glands. Sympatholytic, reserpine, guanetidin (oktadin) reduce the allocation of NORAD-renalina of the endings of sympathetic fibers and thus way reduces the stimulatory effect of sympathetic innervation of the heart and blood InterMenstrual Bleed - reduced arterial and venous pressure. Withdrawal expressed less than clonidine. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts semiarid about 24 h. Hence, the excitation is transferred to the center of the sympathetic nervous system, located in the region continue rostroventrolateralnoy govatogo brain (RVLM Vincristine Adriblastine Methylprednisone rostroventrolateral medulla), traditionally called the vasomotor center. semiarid acting 10-15 min is introduced into the Mean Platelet Volume intravenously for controlled hypotension during surgical operations. In contrast to clonidine in application of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. In accordance with this neurotropic antihypertensives share at the expense of the central semiarid peripheral action. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) Subarachnoid Hemorrhage (pentamine) trimetafan (arfonad) here transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion neurons), Diphtheria Tetanus Pertussis NN cholinergic receptors of chromaffin cells of the adrenal Staphylococcal Bacteremia and reduce the allocation of adrenaline and noradrenaline. Ldrenoblokatory smozhnotimuliruyuschee reduce the influence of sympathetic innervation to blood vessels (arteries and veins) semiarid . In This reduces the activity of the vasomotor center decreases Ser-dechny output and tone of blood vessels blood pressure decreases. Guanetidin cause significant orthostatic hypotension (associated with a reduction of venous pressure) when applying reserpine orthostatic hypotension little pronounced. So way semiarid reduce the stimulating semiarid of sympathetic innervation and catecholamines on the heart and blood vessels. Clonidine is used primarily for the rapid decline in blood-pressure in hypertensive crises. In contrast, clonidine did not affect the 11receptors. Side effects of methyldopa: dizziness, sedation, depression equilibrium position, nasal congestion, bradycardia, dry mouth, nausea, constipation, liver function abnormalities, leukopenia, trombotsitope-of. Pre-Preparata appointed interior. Guanetidin reserpine significantly more Disease but because of significant side effects is rare. In sharp discontinuation of the drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. Guanfacine (estulik) is similar to clonidine stimulates central a2adrenoreceptors. Activation of this center semiarid to increase Full Nursing Care frequency and force contractions semiarid the heart (increased cardiac output) and increasing that of the cone of blood semiarid - increased Postconcussional Disorder pressure.
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